facebook
twitter
rss
760-746-7829

View Location

11770 Bernardo Plaza Court, Suite 458, San Diego, CA 92128.

Natural Medicine For Complicated Conditions
When Nothing Else Has Worked

dr.gaila

 

Dr. Gaila Mackenzie-Strawn

MS, DC, CTN

GI Effects Comprehensive Stool Profile

 

The GI Effects® Comprehensive Stool Profile is an advanced stool test that provides immediate, actionable clinical information for the management of gut health. Utilizing cutting-edge technologies and premier biomarkers, this ground-breaking stool test offers valuable insight into digestive function, gut inflammation, and the gut microbiome — areas affecting not only GI health, but overall health as well.

GI Effects Comprehensive Profile Provides:
A high-level results overview via three major Interpretation At-a-Glance sections
A cover page featuring the clinically actionable Four Functional Pillars as well as two proxy measures of gut health – Commensal Balance and Relative Abundance
The Commensal Bacteria Clinical Associations chart
The Biomarker Clinical Associations chart
Premier stool biomarker testing that gives insight into critical areas of gut health
Digestive function via Pancreatic Elastase 1 (PE1)
Inflammation/Immune function (Calprotectin, Eosinophil Protein X, sIgA)
Gut Microbiome metabolic activity (Short Chain Fatty Acids, n-Butyrate concentration, Beta-glucuronidase) and composition (Commensal (PCR) bacteria, bacteriology and mycology culture, Parasitology via EIA and O & P)
Intestinal Permeability via zonulin – a modulator of intestinal tight junctions, available as an add-on
Why is this the Best Stool Test for GI Diagnostics?
Gastrointestinal function is critical for good health. Emerging evidence has associated overall GI function and gut microbiome status with a wide variety of common illnesses including, but not limited to:

Irritable Bowel Syndrome (IBS)
Inflammatory Bowel Disease (IBD)
Diabetes
Obesity
Cardiovascular Disease
Celiac and Other Malabsorption Disorders
Mood Disorders
Autoimmune
Autism
Add-On Tests
Campylobacter
Clostridium difficile
Escherichia coli
Fecal Lactoferrin
Helicobacter pylori
Macro Exam for Worms
Stool Zonulin
KOH Preparation for Yeast
Clinical Overview

What is the GI Effects Comprehensive Stool Profile?
GI Effects is an innovative stool test measuring premier biomarkers of gastrointestinal function, providing valuable clinical insight into digestive performance, gut inflammation, and the gut microbiome — areas affecting not only GI health, but overall health as well.

The sophisticated biomarkers from the GI Effects Comprehensive Profile are reported using an intuitive DIG framework, providing key clinical information for three main gastrointestinal functional areas:

Digestion/Absorption:
Pancreatic Elastase-1, a marker of exocrine pancreatic function
Products of Protein Breakdown, markers of undigested protein reaching the colon
Fecal Fat, markers of fat breakdown and absorption
Inflammation/Immunology:
Calprotectin, a marker of neutrophil-driven inflammation; produced in abundance at sites of inflammation, this biomarker has been proven clinically useful in differentiating between inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS)*
Eosinophil Protein X, a marker of eosinophil-driven inflammation and allergic response
Fecal Secretory IgA, a marker of gut secretory immunity and barrier function
Additional biomarkers available: Fecal Lactoferrin
Gut Microbiome:
Metabolic indicators, demonstrating specific and vital metabolic functions performed by the microbiota
Short-Chain Fatty Acids, a metabolomic indicator of GI microbiome health
Beta-glucuronidase, an inducible enzyme involved in the metabolism and bioavailability of food and drug compounds; also produced by gut bacteria
Commensal Bacteria, demonstrating the composition, diversity, and relative abundance of gut organisms, all of which are linked to both gastrointestinal and general health
More than 95% of commensal gut organisms are anaerobic and are difficult to recover by traditional (aerobic) culture techniques; molecular DNA techniques are now considered the standard for anaerobic bacteria assessment in research, permitting identification and quantification of multiple organisms with a single specimen.
The Polymerase Chain Reaction (PCR) methodology can identify bacterial populations at any level of taxonomy, as broadly as phylum and as narrowly as species. This ability permits analysis of the gut microbiome at a desired degree of complexity.
GI Effects assesses a key set of 24 clinically relevant genera/species that map to 7 major phyla.
Bacterial and mycological culture, which demonstrate the presence of specific beneficial and pathological organisms
Traditional bacterial culture complements DNA-based tests to provide an expanded survey of a patient’s gut microbiota, beyond the specific organisms targeted by PCR.
Parasitology
GI Effects provides microscopic examination of fecal specimens for ova and parasites (O&P), the gold standard of diagnosis for many parasites.
Enzyme immunoassay (EIA), widely recognized for its diagnostic utility in the detection of pathogenic antigens, is used for the identification of Cryptosporidium, Entamoeba histolytica, and Giardia lamblia.
Determination of one-day or three-day sample collection is based on clinician’s clinical index of suspicion for parasitic infection. If no/low suspicion, a one day sample will likely be adequate. If high suspicion, a three day sample collection is optimal.
Additional Biomarkers Available:
Campylobacter
Clostridium difficile
Escherichia coli
Fecal Lactoferrin
Helicobacter pylori
Macro Exam for Worms
Stool Zonulin
KOH Preparation for Yeast
When Should the GI Effects Comprehensive Stool Profile Be Considered?
GI Effects assesses three critical areas of gut health: digestive function, gut inflammation, and the gut microbiome—areas affecting not only GI health, but overall health as well. For patients with symptoms that may have gastrointestinal dysfunction as their root cause, comprehensive stool diagnostics provide an effective tool for gaining clinical insight into next steps.

In addition to performing critical digestive functions, the intestinal tract contains significant amounts of organisms — the gut microbiome. Imbalances in this internal ecosystem have been associated in the scientific literature with a wide variety of common illnesses including, but not limited to:

Irritable Bowel Syndrome (IBS)
Inflammatory Bowel Disease (IBD)
Diabetes
Obesity
Cardiovascular Disease
Celiac and Other Malabsorption Disorders
Mood Disorders
Autoimmune
Autism

Assessing and normalizing GI function can have profound effects on overall health, leading to improvement in these and other conditions. The GI Effects® Comprehensive Stool Profile is a critical clinical tool in the management of patients presenting with symptoms that can be associated with compromised gut health.

What Advantage Does the Profile Offer Compared to Other Diagnostics?
GI Effects® represents the best technical platform to assess gut health, including an optimized PCR molecular assay for anaerobic bacteria, Matrix Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS) technology for identification of cultivable species, as well as premier biomarkers for stool-based gastrointestinal diagnostics.

The test report is organized so that the clinician may move through results in a logical order that enhances clinical utility, starting with an innovative Interpretation-At-A-Glance pages that are comprised of the following:

Functional Pillars – Using evidence-based rules and weighted algorithms, this page synthesizes patient test results into Functional Pillars of clinical significance (Infection and Imbalance) and provides a directional indication of potential therapeutic next steps in patient management.
Commensal Balance – this infographic has been designed to provide a more precise view of an individual patients’ commensal bacteria (PCR) results relative to a healthy cohort. It is composite of two measures:
The Healthy-Pattern Continuum (formerly known as the Diversity Association Index) is a progressive ranking scale based on a Genova proprietary algorithm that differentiates healthy and unhealthy commensal patterns. This algorithm is applied to an individual patient’s GI Effects commensal bacteria (PCR) findings, and produces a numeric result ranging from 0 to 10 and is denoted by the ‘y’ axis of the Commensal Balance infographic.
The Reference Variance Score reflects the total number of an individual patient’s commensal bacteria (PCR) results that are out of reference range. This number ranges from zero to 24, and is denoted by the ‘x’ axis of the Commensal Balance infographic.
Relative Abundance – this infographic represents the proportional levels of select phyla in an individual’s microbiome and is represented relative to similar measures derived from a healthy cohort of individuals.
Commensal and Biomarker Clinical Associations Charts – to create these charts, Genova utilized the GI Effects test-results database which allowed comparison of commensal and biomarker results in patients with self-reported clinical conditons (IBD, Metabolic Syndrome, Chronic Fatigue, Autoimmune dysfunction, Type 2 Diabetes, High Blood Pressure, Mood Disorders and ROME III criteria (IBS)) to those found in a healthy cohort. In addition, these charts feature patient results marked as high (H) or low (L) compared to the reference range for each commensal bacteria or biomarker.
What Can Clinicians and Patients Expect from GI Effects Comprehensive Profile Stool Testing?
Functional testing can help uncover the root cause of many chronic conditions that often frustrate both physician and patient. The scope of the premier biomarkers on the GI Effects Stool Profile provides comprehensive information to the clinician for the development of strategic interventions. As identified functional imbalances and inadequacies become more normalized through targeted dietary, lifestyle, and supplementation therapeutics, intractable symptoms often improve for many patients.

Each biomarker is associated with specific pertinent therapies, but general therapeutic considerations include:

Discerning general evidence of bowel inflammation and providing intestinal mucosal and anti-inflammatory support
Addressing any identified infection with appropriate pharmacological and botanical treatments
Supporting commensal bacteria with pre/probiotic supplements and dietary changes

A structured diagnostic panel, like the GI Effects Comprehensive Stool Profile, is easier for patients to implement compared to the stressors associated with serial testing. The GI Effects Comprehensive Stool Profile also helps to provide enhanced clinical accuracy in determining which patients may need additional, more invasive testing.

facebook
twitter
linkedin
youtube

About Us

Naturopath & Holistic Doctor San Diego Dr. Gaila Mackenzie-Strawn MS,DC, CTN In 1979, I made a life changing decision. Having suffering with painful abdominal pain since the age of two,Read more

Contact Us

Newsletter